Increasing our health span, is it possible? Yes it is.
As we age, our bodies are affected by many internal processes that are weakening in function and effectiveness. What can we do about this? Diet, exercise, stress management, quality sleep time, etc. are all beneficial areas to address as we age.
It is now understood that aging happens in 3 major stages throughout our lives.
“In terms of biological aging, the body seems to shift gears three times during our lifespans, new research suggests – with 34 years, 60 years and 78 years the key thresholds.
In other words, we now have evidence that aging isn’t one long, continuous process that moves at the same speed throughout our lives.”
If you knew of a simple way to prevent a significant cause of age related conditions, would you want to take advantage of the latest science to improve your health span?
If yes, then read on.
Aging is not a Disease
Aging is not a disease but an accumulation of damage to various physiological and psychological systems over time.
Time is limitless or is it?
Regular clocks are deceptive, they go in never ending circles or they have never ending numbers. For living beings this is a fallacy, consider that our lives are more like an hour glass with the sand running out.
You can slow down the sands of time, if you try.
Diseases are defined in the ICD11 document, which the medical field uses to establish accepted methods of treatment. Aging is not on this list.
Hallmarks of Aging
Currently there are 9 Hallmarks of Aging and they each have scientific merit.
Some Hallmarks of Aging are easily addressable, some are not.
The “Hallmark of Aging” to be addressed by the initial series of senolytic programs designed by Combilytics Corp, is now recognized as a “root cause” of many age related diseases and conditions. As well as contributing to 5 of the other Hallmarks of Aging.
Scientists have known about the presence of senescent cells within the human body for over 30 years. As cancer research moved forward, there was an ever increasing body of work suggesting that senescent cells have similar properties to cancer cells in how they protect themselves against the body’s natural process of cellular death, autophagy and apoptosis.
Since 2015 it has become abundantly clear to the scientific community that senescent cells are one of the most significant contributors to age related diseases. Additionally, research demonstrates that clearing these cells from the aging body will allow the body to heal in areas affected by these cells.
THE PROBLEM - Senescent or Zombie cells
The cells in our bodies replicate on a regular basis and depending on the cell type (there are over 240 types) it can be fairly quick, like skin cells replicating every 30 days or slow, like bone cells replicating every 10 years. Or never, like the cells in the lens of your eye.
Some of our cells stop replicating but continue to live in a way that is harmful to our bodies.
These immortal Zombie cells enter a state of “replicative senescence”, i.e. senescent cells. They stop replicating but don’t die. They won’t die naturally and as long as nothing is done to clear them, they will live as long as you will and they will accumulate to a point where they become extremely harmful to you.
How do senescent cells differ from regular cells?
A significant number of your 240 cell types replicate over time. There are a few cells types that do not replicate, such as the lens cells in your eye.
Damaged and older cells accumulate mutations which, if allowed, will replicate their harmful mutations in new cells potentially causing cancer and other diseases.
Fortunately, these damaged cells may instead develop what is called “replicative senescence” which means they are unable to replicate like a damaged “normal cell”. This stops the damaged cell from becoming cancerous. Replicative senescence is part of the natural life cycle of cells and an evolutionary defence mechanism intended to prevent harm to the living organism.
Normally, the majority of cells with replicative senescence are purged or cleared from the body through the actions of the immune and other systems. As the immune system becomes compromised with age and becomes impaired by it’s own senescent cells, fewer of these zombie cells are cleared.
Because senescent cells are a natural progression for cells, this is not considered a disease.
Why is it a problem, having senescent cells in our body?
This resistance to cell death (autophagy) is enabled by the continuous emission of chemical signals that senescent cells produce. They produce these chemicals to signal the natural cell recycling and cleaning processes to leave them alone.
Senescent cells are protecting themselves from cell death by inhibiting your immune system.
As documented by the Buck Institute on Aging, there are over 500 known chemicals emitted by senescent cells and this emission is called SASP, (senescence-associated secretory phenotype). Many of these chemicals cause inflammation which in itself is a significant cause of many diseases and chronic conditions. Just 1 of these zombie cells in 15,000 causes measurable damage.
Another harmful aspect of senescent cells is neighbourhood recruitment.
A few of the known types of emissions from senescent cells.
Neighbourhood recruitment. Another harmful aspect of senescent cells
As senescent cells accumulate, the combined SASP emissions affect the cells nearby and re-programs them to become senescent. To date 4 of these signalling chemicals have been clearly identified as influencing nearby cells to become senescent.
The more senescent cells there are, the faster they accumulate.
This cascade effect generates more senescent cells to beget even more senescent cells. This is easily seen in older people who “go down hill” rapidly and often unexpectedly.
If zombie cells are so bad why do we have them? Is there a purpose for senescent cells?
Senescent cells are not inherently bad when people are young (under 35), as they play a key role in wound healing by stimulating inflammation which is required for wounds to heal.
Senescence is also the first line of defence against cancer in people under 35 years old.
As cells are in the process of living, replicating and recycling, they have 3 pathways to the future;
- recycle or replicate in a normal way that enables a healthy life
- become corrupted and turn into some form of cancer or other disease
- become corrupted and enter the senescent phase and divert away from cancer at an early age or
- as we age, senescent cells become a contributing factor for many age related diseases
As we age, the benefits of senescent cells become harmful
As we age, the immortal zombie cells accumulate and the SASP emissions overpower our defence systems.
How many of these senescent cells do we have?
It is estimated that when we are born we have about 5% of our cells already in senescent mode. As we know, senescent cells in low numbers help protect us from cancer, fibrosis and enhance wound healing.
Every insult or injury creates more of these immortal cells until the day we die and it is estimated that at typical end of life an 80 year old would have up to 17% senescent cells.
This means a person weighing 180lb would have approximately 30lb of zombie cells in their body. Without some type of intervention to clear a significant portion of these cells down to a youthful level, they will contribute to ongoing harm.
Our cells are programmed to replicate, but as they age the replication process becomes less effective.
We have over 240 cell types in our body and 37 trillion of them!
While not all cells can become senescent and turn to zombies, the majority can suffer from this conversion.
Skin cells replicate approximately every 30 days, red blood cells every 3-4 months, our bone cells every 10 years. The body’s recycling process for normal healthy cells is called autophagy and is the body’s natural recycling process for cells which are at their end stage.
To clear established “bad” cells like senescent and cancer cells that do not respond to autophagy, the process is called apoptosis, i.e. inducing cell death. This happens naturally in some cases but again, as we age, our protective systems are weakened to the point where help is needed or nature takes it course and we continue to accumulate harmful senescent cells.
What conditions do Zombie cells have an effect on?
There is now a large body of scientific literature that suggests that many diseases are either linked to or triggered by the presence of senescent cells. A short but incomplete list includes;
- rheumatoid arthritis,
- heart disease,
- macular degeneration,
- COPD (Chronic obstructive pulmonary disease),
- type 2 diabetes,
- age related depression,
- and as many as 15 types of brain diseases including Alzheimer’s and Parkinsons
A recent study at Western University in London, ON indicates that aortic aneurysms are caused by senescent cells. This disease is a silent killer and kills over 1,500 Canadians and over 15,000 Americans every year and increasing, due to our aging population.
Albert Einstein, Lucile Ball, John Ritter and Allen Thicke all died from aortic aneurysms. Abdominal aortic aneurysms are the third leading cause of sudden death in men over age 60.
Try this little experiment with your favourite search engine. Pick your favourite disease or condition and add senescent cells to the end. For example “metabolic disease senescent cells“or “heart disease senescent cells” and you may be surprised at the results.
The Solution - Natural Senolytics
You now have an opportunity to do something to potentially increase your health span, are you ready to fight aging with the latest science?
Senolytics are small molecule compounds that cause senescent cells to die, i.e. induce apoptosis.
Aging is not classified as a disease.
For example, in the future, if you have osteoarthritis of the knee you will be able to get a senolytic drug for that BUT if you don’t have that disease in your knee you won’t be able to get that drug. Drugs are disease specific, highly regulated and Doctors can only prescribe a drug that is approved for a specific disease. The FDA and Health Canada do not recognize aging nor senescent cells as a disease and this will limit who gets these wonder drugs.
The top 2 natural senolytic compounds identified today are;
- Fisetin – the compound that makes strawberries red
- Quercetin – a compound found in apples and onions
EternLFX - by Combilytics Corp
EternLFX utilizes 2 of the top rated natural senolytics, Quercetin and Fisetin.
Why would we use 2 natural senolytic compounds? To maximize the synergistic effect of multiple compounds working on similar pathways in our body. This approach, using similar and complementary drugs in combination is commonly used in the pharma industry.
- Quercetin – a natural senolytic derived from apples and other plants
- Fisetin – a natural senolytic derived from strawberries and other plants
- EGCG – from green tea is a kinase and mTOR inhibitor
- Vitamin E – this compound helps increase the availability of Quercetin for the brain.
- Bromelain – a natural digestive and inflammation reducer derived from pineapples
- PLUS – 4 natural bio-availability enhancers to increase effectiveness